Director, Preclinical Research and Discovery

permanent vacancy
Written By Karma El Chalabi

The Director, Preclinical Research and Discovery, leads the preclinical strategy for the lead asset and pipeline programs. This includes overseeing the preclinical research daily activities, team, and budget.

Our headquarters are in London and we are a remote-friendly employer. We have team members across countries in Europe and North America.

Roles and responsibilities

  • Lead the Preclinical Research and Discovery strategy for the lead asset and pipeline programmes

  • Oversee the Preclinical Research and Discovery daily activities, team, and budget including contingency planning

  • Generate new pharmacology data to required standards and build hypotheses for product development in relevant therapeutic areas, including sexual dysfunctions and mood disorders

  • Manage relationships with third parties to deliver on the strategy, including relevant contract research organisations (CRO), development/commercial partners, and academic centres

  • Review and oversee Preclinical submissions to and interactions with regulatory agencies including the FDA (US), the MHRA (UK), the EMA (EU), and the TGA (Australia) amongst others as relevant

  • Collaborate with Clinical Development colleagues, including the Chief Medical Officer and clinical operations, to design relevant clinical trials and protocols

  • Collaborate with Intellectual Property colleagues to identify and secure opportunities for IP arising from Discovery and Preclinical Research activities

  • Ensure preclinical studies are run in accordance with appropriate standard operating procedures (SOP) and relevant regulatory guidelines

  • Ensure the design of the nonclinical programme for the lead asset (and pipeline when relevant) is compliant with ICH requirements for the stage of development, facilitating efficient progress across phases

  • Maintain and apply Preclinical GxP and H&S knowledge to relevant activities, including through relevant trainings

Experience, skills and qualifications

  • Degree in Pharmacology or other appropriate scientific discipline, higher degree/postgrad qualification level strongly preferred (e.g. PhD)

  • Significant experience including in senior positions within Pharmacology and Preclinical functions of a pharmaceutical company or equivalent

  • Knowledge of relevant legislation and guidelines pertinent to preclinical drug development and pharmaceutical drug development

  • Relevant experience in scientific technical writing including for regulatory documents, grant submissions and scientific publications (published work preferred)

  • Experienced in presenting key data at national and international meetings

  • Competence in budgetary control and management

  • Proven organisational and time management skills

  • Strong problem solving skills

  • Experience leading, managing and developing others

  • Strong written and oral communication skills

  • Working knowledge of Excel, Word, PowerPoint, Endnote, search engines and databases used for literature searches, and relevant scientific software (e.g. GraphPad)

To apply, please send your CV to careers@kadencebio.com

Karma El Chalabi